Clinical and Translational Issues Working Group - 2014 MSM

Clinical and Translational Issues Working Group

Current & Upcoming:

Annual MSM Meeting Oct 2-3, 2013 Working group schedule: WG Breakout Session on Day 1 (10/2) right after lunch from 1-2pm Report on your WG during the 3-4pm session on Day 2 (10/3)

General Questions: identify models that have actually made their way into the clinic. Many of these will not be multiscale but can be thought about both in terms of making them multiscale and in terms of simply seeing how such software has been successful in making the transition from research world to clinical world. Models that come to mind are models of cardiac arrhythmias that might be playing a role in decisions on internal wire placements and ablations; anatomical body models that play a role in planning of radiation therapy.

Specific topics: 1. Seeking NSF sponsorship for focused meeting on Modeling for the Clinical Enterprise 2. Special issue of journal based on this meeting 3. Case-based examples: what models are in the clinic? what models may be ready to bring to clinic?; how to move those projects that are not ready so as to make them ready?

Agenda: Presentation on [1]Committee on Credible Practice of Modeling & Simulation in Healthcare Description by Ahmet and Lealem

Webinar Mon, Sep 16, 2013 15:00 IMAG Clin/Trans webinar

  • Bridget Wilson, PhD U New Mexico ( will speak on tumor modeling: Model for Ovarian tumor relapse
  • Mark G. Davies, MD PhD MBA, Methodist Hospital will speak on modeling Abdominal Aortic Aneurysms: Multiscale Modeling of AAA for the monoscale clinical application

Working Group leads: Bill Lytton, Marc Garbey

Goals and Objectives:

MSM is fundamentally a scientific pursuit but one with strong engineering implications.

There is a long, well-established, empiric tradition in medicine which has been reinforced recently by the rising popularity and important of evidence-based medicine (EBM). The reverse of the empiric approach is an understandable skepticism regarding all things merely theoretical or hypothetical.

We face an uphill battle in getting modeling of any kind noticed, accepted and used in medicine.


Jeff Arle, MD PhD FAANS Title: Professor, Dept of Neurosurgery Affiliation: Beth Israel Medical Center, Harvard, Boston, Ma Keywords: Spinal Cord, Neurosurgery, Neural modeling

Frank Barone, PhD Title: Professor, Dept of Neurology Affiliation: Downstate Medical Center, Brooklyn, NY Keywords: Stroke, Cerebrovascular accident (CVA), Brain ischemia

Barbara Lee Bass, M.D. Title: John F. and Carolyn Bookout Distinguished Endowed Chair The Methodist Hospital Department of Surgery, Executive Director - Methodist Institute for Technology Innovation and Education (MITIE), Professor of Surgery - Weill Cornell Medical College Affiliation: The Methodist Hospital Website:, Keywords: Breast Cancer Tissue Modeling, Surgical Education, Comparative Effectiveness.

Scott Berceli, M.D., PhD Title: Associate Professor of Surgery Affiliation: University of Florida Website: Keywords: Hemodynamics, Vein Graft, Intimal Hyperplasia, Systems Biology, Shear Stress, Genomic Analysis, Bayesian Network, Agent-based Modeling.

Colleen Clancy, PhD UC Davis

Thierry Colin, PhD Title: Professor in Applied Mathematic Affiliation: Institut Polytechnique de Bordeaux and INRIA Bordeaux-Sud-Ouest Website: Keywords: Cancer, Computational Modeling of Tumor Growth, Multi-scale Mathematical Modeling, Microfluids, Partial Differential Equations.

Clifford C. Dacso, MD, MPH, MBA, Professor, Molecular & Cell Biology and Medicine, Baylor College of Medicine, Methodist Hospital

Mark G. Davies, M.D., PhD, M.B.A. Title: Professor of Cardiovascular Surgery Affiliation: Methodist DeBakey Heart and Vascular Center & Weill Cornell Medical College Website:, Keywords: Cardiovascular Biology, Cardiovascular Imaging, Cardiovascular Interventions, Smooth Muscle Cell Biology, Proteases Biology, Vessel Wall Injury, Clinical Outcomes.

David M. Eckmann, PhD, MD Title: Horatio C. Wood Professor of Anesthesiology and Critical Care, and Professor of Bioengineering Affiliation: University of Pennsylvania Website: Keywords: Targeted Drug Delivery, Interfacial Mechanics, Cellular Mechanotransduction

Anthony C. Hunt This article on grounding in MSM has been published in Theoretical Biology and Medical Modelling: Relational Grounding Facilitates Development of Scientifically Useful Multiscale Models C. Anthony Hunt, Glen E.P. Ropella, Tai ning Lam and Andrew D. Gewitz

Tara Klassen PhD Assistant Professor Affiliation: Faculty of Pharmaceutical Sciences University of British Columbia Website: Keywords Protein homology modeling, ion channel mutations, epilepsy genetics, translational bioinformatics, in silico risk prediction, multi-state modeling, neuronal/network models, personalized medicine.

Mark Kramer, Boston University, mak@math.bu.edu

Tommaso Mansi, Siemens,

Vasilis Marmarelis PhD Title: Professor of Biomedical Engineering Affiliation: University of Southern California Website: Keywords: Cerebral Hemodynamics, Vasomotor Reactivity, Alzheimer's Disease, Dementia, MCI, Neurostimulation, Diabetes, Model-based Diagnostic Physiomarkers.

Benjamin Ribba, PhD Title: Junior Researcher at INRIA 'Affiliation:Rhone-Alpes Website: Keywords: Computational Modeling of Tumor Growth, Modeling in Infection Diseases, Partial Differential Equations, Mixed-effect Models, Pharmacokinetics, Pharmacodynamic.

Gordon MG Shepherd, Northwestern University,

Kristin Swanson, PhD Title: Associate Research Professor, Pathology & Adjunct Associate Research Professor, Applied Mathematics Affiliation: Department of Pathology, University of Washington Website: Keywords: Glioma, Brain Cancer, Personalized Mathematical Oncology, In Silico Tumor Growth.

Roger Tran-Son-Tay, PhD Title: Professor Affiliation: University of Florida Website: Keywords: Characterization of Biological Viscous and/or Elastic Fluids (blood, synovial fluids,...), Measurement of Blood Cells Properties (mechanical properties, deformation, adhesion), Cell Damage Assessment, Application to Vein Graft and Cancer.

Yoram Vodovotz, Ph.D. Director, Center for Inflammation and Regenerative Modeling Professor of Surgery, Immunology, Computational and Systems Biology, Clinical and Translational Science, and Communication Science and Disorders University of Pittsburgh W944 Biomedical Sciences Tower 200 Lothrop St. Pittsburgh, PA 15213 E-mail: Phone: 412-647-5609 Direct: 412-648-3758 Fax: 412-383-5946 Cell: 412-585-0115

Sarah Ying Pfizer

Dr. Tom Yankeelov; U01 award “Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer”.

See main wiki listings for contact information on the following:

David D'Argenio

Paolo Vicini

Paul Jasper

Terry Sanger

Donna Lochner

Bridget Wilson

Andrew McCulloch

Gary An

MSM Meetings

2013 Meeting

Related Meetings

Annual ORNL Biomedical Science and Engineering Conference Collaborative Biomedical Innovations: The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience May 6-8, 2014 - Oak Ridge, Tennessee: Featuring Workshop on "States of the Multi-Scale Brain in the Time Domain" [[2][Website]]


Annual MITIE Research Report 2013 Media:MITIEReport4_compress.pdf


[Webinar] Tuesday, March 25, 2014 15:00

Mathematical models for tumor growth: construction, validation and clinical applications.

Thierry Colin, ENSEIRB-MATMECA, Institut Polytechnique de Bordeaux, Inria Bordeaux-Sud-Ouest EPI MC2 Institut de Mathématiques de Bordeaux

[3][Webinar] Friday, May 3, 2013 15:00

Barbara Lee Bass, MD, FACS John F. & Carolyn Bookout Distinguished Endowed Chair Department of Surgery, The Methodist Hospital Director, Methodist Institute for Technology, Innovation & Education Professor of Surgery, Weill Medical College of Cornell University


Min Kim, M.D. Assistant Professor of Surgery Weill Cornell Medical College Department of Surgery The Methodist Hospital

Barbara will talk on Breast Conservative Therapy,

Min will talk on Tumor Metastasis: absrtact: Tumor metastasis is the most important stage of tumor development. To date, there is no in vitro or ex vivo model that can mimic tumor metastasis. We have developed a novel 4D model of lung cancer tumor growth and metastasis. The model can isolate the tumor cells at different phases of development at the primary tumor, circulating tumor cells and metastatic lesions. This model may allow us to better understand the biology of tumor metastasis and may provide insight to the novel targets to stop metastatic spread of lung cancer.

On March 14, 2013, from 10 AM to Noon PDT there will be a webcast

tutorial on how to use the Neuroscience Gateway (NSG) portal to run simulations on parallel supercomputer hardware. There is no charge for this hands-on workshop, but registration is required and space is limited so be sure to sign up early. For more information about the webcast see and for more information about the NSG see

1. Another (nonmonotonic) "scale" to think aboutin vitroin vivo normal, in vivo pathological, human normal, patient. Discussion

2. How to make connections with clinicians: invite clinicians to give webinar talks -- propose their wishlists of problems that models might help solve.

3. Bring basic scientists to learn clinical surgery for 3 days at MITIE.

4. See main page for upcoming meeting: Computational Surgery in Boston Dec 9-11. Link


Tuesday, September 18, 2012 3-4pm EST

MSM of Experimental Applications for Clinical and Protoclinical Techniques for Neurological and Psychiatric Disease

We will have 3 presentations by individuals exploring different levels of analysis both experimentally and clinically, each with corresponding modeling efforts attempting both to fit the level being immediately explored and reach up or down for further scales.

  • James Schwaber (Jefferson U) will present his recent work revealing the transcriptome of the neural cell as a source of its dynamical variability and its vulnerability to disease. This work has applications both to neural disease and to hypertension.
  • Rhonda Dzakpasu (Georgetown U) will describe the development of an in vitro preparation consisting of dissociated hippocampal and striatal neurons that might be used to screen possible neuropharmacological agents for neurological and psychiatric disease.
  • Ahmet Omurtag of the Biosignal Group will present recent results on the use of a novel EEG "cap" utilized to evaluate alterations in brain waves in patients admitted to the Emergency Department.
Connection Info:
Audio: 800-369-3313, passcode: 29060

Friday, September 23, 2011 3-4pm EST

TITLE: Preparation for 2011 MSM Meeting

Discussion will focus on aligning clinical expectations and requirements for modeling with a realistic appraisal of what can be accomplished with the tools currently available. We will discuss the possible pathways for more extensive use of computer simulation directly in clinical pathway, noting administrative, technical, regulatory, equipment and cost limitations. We will also discuss how basic science can best be brought into the loop both to obtain better parameterizations of models and to develop techniques to allow the direct patient assessments needed to personalize the simulation to the individual patient. Focus of discussion will necessarily be on the areas of expertise of the participants, but we would also encourage both participants and audience to consider other areas of medicine that might benefit from the multiscale modeling approach.


Bill Lytton -- Introduction (5 min)

Barbara Bass-- Breast reconstructive surgery -- potential and pitfalls for modeling (15 min)

Frank Barone -- Ischemic penumbra (stroke) -- potential and pitfalls for modeling (15 min)

Scott Berceli -- Vascular repair -- potential and pitfalls for modeling (15 min)

Marc Garbey- Wrap up and points for further discussion (10 min)


Monday, April 25, 2011 3-4:30pm EST

TITLE: From multiscale to patient-scale?
ABSTRACT - Discussion Guide
Robert Gatenby, MD -Chair, Department of Integrative Mathematical Oncology and Chair, Department of Diagnostic Imaging – Moffitt Cancer Center, media: Gatenby_talk.pdf‎
Bill Lytton, MD – Professor of Physiology and Pharmacology, Neurology, Biomedical Engineering – Suny Downstate – Medical Center, media: Lytton_talk.pdf‎
Scott Berceli, MD – Professor of Surgery, Head of the The Vascular Biology Research Laboratories, University of Florida, media: Berceli_talk.pdf
Marc Garbey, Professor of Computer Science and Mathematics, University of Houston & Department of Surgery at The Methodist Hospital, media: Bass_Garbey_talk.pdf‎

Musings on State of the Art:

Cardiology I think that this is the most advanced field in MSM and the one that has the most immediate implications for clinical practice. A question: is explicit modeling utilized clinically?-- eg perhaps for assisting in determination of ablation sites in arrythmias. Does anyone know of a cardiologists or a researcher in cardiology who could help with this.

Neurology Epilepsy modeling is starting to be used to help determine what is normal and what is abnormal activity in order to identify a primary epileptic focus. This modeling is mildly multiscale since involves both neural and network levels.

Pulmonary Interactions between neural, mechanical and chemical levels.

Surgery Surgery is traditionally purely macro but there is increased interest in immediate or prolonged drug infusions so as to treat at the micro level as well. Such an approach would seems to be particularly useful for cancer surgery. MSM would be a natural partner for this kind of mixed approach.

Infectious disease Lots of interesting host/pathogen interactions. Is this modeled as predator/prey?

Rheumatology Immune system is a complex system with many feedback loops which would clearly benefit from detailed modeling.

Orthopedics Bone remodeling, healing.

Others ...

Challenges and Opportunities:

As above -- MDs are hardnosed folk who are skeptical of the theoretical and hypothetical.

Journal Articles:

(Feel free to cite yourself -- we need to learn what each other does and knows; Annotate and provide pointers when available)

M. Garbey, B. L. Bass and S. Berceli, Multiscale mechanobiology modeling for surgery assessmentActa Mechanica Sinica 28:1186-1202,2012 PDF

FYI:Pubmed seach translation "multiscale modeling" returns 2, neither of which seems to be focused on translation.

 author =	"Noble, D",
 title =	"Modeling the heart--from genes to cells to the whole organ."
 journal =	"Science",
 year =	"2002",
 volume =	"295",
 pages =	"1678-1682",

Exemplary example of MSM with applications to cardiology. Question: how many clinical papers have cited this paper? If cited has there been implications for practice or simply used as general background in the intro?

 Lytton WW.  Judgment-based medicine; response to "Evidence-based medicine or
 faith-based medicine?" (letter) Med. Gen. Med. 7(1):33, 2005. PMID: 16382513

OK -- this is not exactly an article but this is a musing, somewhat amusing, on the issue of keeping basic science relevant in clinical practice. I suggest that "Judgment-based medicine," utilizing underlying pathophysiological understanding, must still complement evidence-based medicine. EBM by itself will never be able to drive medical practice.

 Lytton WW. Computer modelling of epilepsy. Nat Rev Neurosci 9:626-637. PMID: 18594562. 2008. 

Review of modeling for epilepsy [4]

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