Bridging biological scales by linking agent-based models to intracellular and continuum biomechanics models
As high-quality and high-throughput biological data at multiple different levels of spatial scale (gene through tissue) become increasingly available, we are tempted to define the cause-and-effect biological relationships that span across spatial scales with greater mechanistic detail. Doing so provides an opportunity to probe, for example, how receptor-ligand interactions in the membrane of one cell impacts the migratory behaviors of a neighboring cell, and, ultimately the mechanical properties of a remodeling blood vessel—and vice versa.