Return to 2015 MSM Consortium Meeting
Meeting Agenda
2015 MSM Consortium Meeting, The Interagency Modeling and Analysis Group
Lister Hill Center, National Institutes of Health Main Campus, September 8-9, 2015
Satellite Meeting September 10, 2015
Day 1: Tuesday September 8th
8:00 – 8:30am: Check-In, Set up Posters
8:30 – 8:50am: Welcome
2015 MSM Co-chairs - David Eckmann and Marc Garbey
IMAG - Grace Peng
NIBIB - William Heetderks
8:50 –10:20am: THEME 1, Part A - Bio-medical Multiscale Modeling Success Stories and Lessons Learned (Moderator: Mark Alber)
Theme 1 Goal and Charge to Speakers
- 8:50-9:30am: Steve Railsback (Keynote) - Fifteen years experience modeling fish population response to river management: Lessons learned and strategies for success
- 9:30-10:00am: Melissa Knothe-Tate - The power of coupled multiscale imaging and modeling - How good is good enough?
- 10:00-10:30am: Jennifer Linderman - An in vivo systems biology approach to understanding and treating tuberculosis
10:30 – 10:50am: Refreshments* and Poster Viewing
10:50 – 12:20pm: THEME 1, Part B - Bio-medical Multiscale Modeling Success Stories and Lessons Learned (Moderator: Lealem Mulugeta)
Theme 1 Goal and Charge to Speakers
- 10:50-11:20am: Weiyong Gu - Multiscale and Multi-physics Modelling of Degenerative Disc Disease and in silico Clinical Trials for Disc Repair
- 11:20-11:50am: Madhav Marathe - Responding to the Ebola Outbreak: Computational Epidemiology in the age of big data and high performance computing
- 11:50 – 12:20: Theme 1 Panel discussion
12:20 – 1:20pm: Lunch on your own (Lister Hill or Natcher, Bldg. 45)
1:20 – 2:10pm: Working Group Breakout Session A
| Working Group (WG) | Meeting Location | WG Lead |
| Biomechanics | Auditorium Area 1 | Beth Winkelstein |
| Multiscale Systems Biology | Auditorium Area 2 | Ronan Fleming, Mark Alber, Feilim Mac Gabhann |
| Computational Neuroscience | Lobby Area 1 |
Ted Berger, Bill Lytton, Raj Vadigepalli |
| Theoretical and Computational Methods | Lobby Area 2 | George Karniadakis |
| Model and Data Sharing | Alcove Area 1 |
Herbert Sauro, Jim Bassingthwaighte |
| Committee on Credible Practice of Modeling & Simulation in Healthcare |
Alcove Area 2 |
Lealem Mulugeta and Ahmet Erdemir |
2:10 – 3:00pm: Working Group Breakout Session B
| Working Group (WG) | Meeting Location | WG Lead |
| Biomechanics | Auditorium Area 1 | Muhammad Zaman |
| Cell-to-Macroscale | Auditorium Area 2 | Ed Sander, Ching-Long Lin |
| Population Modeling | Lobby Area 1 | Madhav Marathe and Paul Marjoram |
| Integrated Multiscale Biomaterials Experiment and Modeling Group (ImuBEAM) | Lobby Area 2 | Brian Carlson |
| Clinical and Translational Issues | Alcove Area 1 | Marc Garbey and David Eckmann |
| High Performance Computing | Alcove Area 2 | Ravi Radhakrishnan |
3:00 – 4:30pm: Refreshments* and Poster Viewing (Return to Lister Hill Auditorium)
3:00 – 3:45pm – Poster Presenters in Group 1 stand by their posters
3:45 – 4:30pm – Poster Presenters in Group 2 stand by their posters
4:30 –5:30pm: New U01 Awardee Presentations (10 minutes each)
- Bill Lytton - Microconnectomics of primary motor cortex: a multiscale computer model
- Saleet Jafri and Jon Lederer - Multiscale studies of mitochondrial calcium cycling
- Mark Alber - Multiscale modeling and empirical study of a mechanism limiting blood clot growth
- James Moore - Fluid Pumping and Mass Transfer in the Lymphatic System
- Ross Carlson - Predictive Multiscale Modeling of Microbial Consortia Biofilms
- Jason Haugh - Multiscale modeling of wound healing
6:30pm: Group Dinner: Shangri-La Nepalese & Indian Cusine, 7345 Wisconsin Ave, Bethesda, MD 20814
Day 2: Wednesday, September 9th
8:00 – 8:20am: Check-In
8:20 – 8:30am: Welcome Back!
8:30 – 9:00am: IMAG Initiative Updates
- IMAG MSM U01 (PAR-15-085) —Grace Peng, Manana Sukhareva
- NCI Cancer Systems Biology Consortium Initiative - Dan Gallahan and Shannon Hughes
- BRAIN Theories R01 (RFA-EB-15-006) - Grace Peng
- DoD Medical Simulation and Training initiatives - Kevin Kunkler
9:00 – 10:30am: THEME 2 - Multiscale Modeling Implementation into Medical Simulators/Trainers (Moderator: Marc Garbey)
Theme 2 Goal and Charge to Speakers
- 9:00-9:20am Iwona Jasiuk - Modeling approaches for simulations of tissue deformations during robotic surgery
- 9:20-9:40am Thomas Talbot - Design Approach to a Working Virtual Conversational Patient for Medical Education
- 9:40-10:00am Suvranu De - MSM algorithms for medical simulator design
- 10:00-10:05am Marc Garbey – COSINE5 meeting recap
- 10:05-10:30am Theme 2 Panel Discussion
10:30 – 11:00am: Refreshments* and Poster Viewing
11:00 – 12:30am: THEME 3 - Multiscale Modeling for Optimal Disease Diagnosis/Treatment Applications (Moderator: David Eckmann)
Theme 3 Goal and Charge to Speakers
- 11:00-11:10am Maciej Swat - Virtual-tissue computer simulations
- 11:10-11:20am Scott L. Diamond - Coarse graining data-driven cellular models in multiscale simulations
- 11:20-11:30am Gary An - The meaning of parameter space in the context of clinical populations: lessons from the simulation of 80 million sepsis patients
- 11:30-11:40am Feilim Mac Gabhann - From proteins, viruses and cells to patient populations: simulations of potential HIV cures
- 11:40-11:50am Jean-Marie C Bouteiller - From biomolecular events to neuronal network dynamics: Efficient scale-linking enables higher levels of integration
- 11:50-12:00pm Don Bolser - Value of computational modeling in understanding human pulmonary defensive reflexes
- 12:00-12:30pm Theme 3 Panel Discussion
12:30 – 1:30pm: Lunch on your own (Lister Hill or Natcher, Bldg. 45)
1:30 – 2:00pm: IMAG Representatives Grant Process Overview / Lightning Presentations
- NSF - Sridhar Raghavachari
- NIH - Susan Volman
- NHLBI - Albert Lee and Pankaj Qasba
- NCCIH - Wen Chen
- DoD - Kevin Kunkler
2:05 – 3:10pm: Refreshments* and Table Chats with IMAG Representatives
3:10 – 3:30pm: Annals of BMES Special Issue on MSM – Tom Yankeelov
3:30 – 3:45pm: IEEE EMBS TBME Special Issue on Model Reproducibility – Ahmet Erdemir & Herbert Sauro
3:45 – 5:00pm: MSM Consortium Discussion
MSM Consortium Goals and Structure—IMAG
Plans for 2016 Consortium meeting—All
Highlights from Working Group breakouts—2015 WG leads o Accomplishments from 2015
Multiscale Systems Biology - Ronan Fleming, Mark Alber, Feilim Mac Gabhann
Biomechanics Working Group - Yasin Dhaher
Cell-to-Macroscale Working Group - Ching-Long Lin and Ed Sander
Clinical and Translational Issues Working Group - Marc Garbey and David Eckmann
Committee on Credible Practice of Modeling & Simulation in Healthcare - Lealem Mulugeta and Ahmet Erdemir
Computational Neuroscience Working Group - Ted Berger, Bill Lytton, Raj Vadigepalli
Population Modeling Working Group - Madhav Marathe and Paul Marjoram
Model and Data Sharing Working Group - Herbert Sauro
Theoretical and Computational Methods - George Karniadakis
High Performance Computing Working Group - (Ravi Radhakrishnan), TBD
Integrated multiscale biomaterials experiment and modeling group (ImuBEAM) - Brian Carlson
Transitioning WGs and WG co-leads, Proposals for New WGs
5:00pm: Meeting Adjourn
*Refreshments courtesy of the IEEE Engineering in Medicine and Biology Society – Thank You!
Day 3: Thursday September 10, 2015
Overview and Use of Standards and Formats Relevant to MSM - Mike Hucka, Jim Sluka, Herbert Sauro
Concurrent Meeting
NHLBI Systems Biology Meeting (for NHLBI awardees) - Pankaj Qasba