NOTE: XSIM is NO Longer supported!
XSIM Interface Tour
We have provided a tutorial and tour through XSIM that demonstrates many of its capabilities (video clips are provided for MS Windows users; an X server is not required.
- Flow through a pipe.
- A simple model for Michaelis-Menten reaction.
- Two enzymes in vesicle.
- A set of nonlinear transmembrane transporters (tutorial available).
Single capillary-tissue unit
- A two-compartment blood-tissue exchange model.
- A two-region, distributed blood-tissue exchange model.
- A four-region, distributed blood-tissue exchange model.
- A multi-path, multi-indicator, four-region organ model (tutorial available).
- A multi-path, multi-species, four-region organ model.
- A multi-path, multi-species, five-region organ model with nonlinear transmembrane transport, nonlinear reactions and time-varying blood flow and volume (tutorial available).
- A model of coupled solute-solvent exchange between two compartments.
- A model of solute and water fluxes in a whole organ.
Action potential models
- Hodgkin-Huxley model for membrane conductance.
- Modified Luo-Rudy dynamic model of the guinea pig cardiac ventricular action potential in a single cell.
- An ion channel model recently developed by J. L. Greenstein to study the "Role of the Calcium-Independent Transient Outward Current Ito1 in Shaping Action-Potential Morphology and Duration" (Circ Res. 87:1026-1033, 2000).
- Action potential model for canine ventricular cell (Winslow-Rice-Jafri model version 3) that incoporated the above Ito1 model developed by J. L. Greenstein el al.
- Modification of wrj3 by A. Michailova and A. D. McCulloch.
- Decaying sine, cosine, and tangent waves.
- A demo to illustrate the theory and method of the axially-distributed blood-tissue exchange model (video clips for MS Windows users).
Model development and archiving support at https://www.imagwiki.nibib.nih.gov/physiome provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.