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Guidelines for Credible Practice of Modeling and Simulation in Healthcare

Modeling osmotic transients during exercise

Impact of Compartmentalization and Cell Shape on Signaling Pathways in Cancer

in silico and in vitro analysis of resource allocation in a chronic wound biofilm consortia

Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis

Computational Game Theory for Antibody Design

Eugene

Understanding the Role of Mitochondrial Cristae Structure on Energy Metabolism through Simulation

Multiscale Modeling of Wound Healing

molecules (1e-2 Da to 1e6 Da), cell

A multiscale model of metabolism and protein expression predicts the response of E. coli to oxidative stress

Spatial Scaling in Multiscale Models: A Method for Coupling Agent-based and Finite-element Models of Tissue Remodeling

Mechanistic Models, Model Mechanisms, and Computational Models of Explanation for Biological Phenomena

Is the Mechanism of APAP Toxicity In Vivo & In Vitro really the same?  A model mechanism based explanation of the in vitro–in vivo disconnect

Structural biomechanics of platelet-driven clot contraction

High-Fidelity Controlled-Resolution Atlas and Deformable Model-based Anatomical Modeling for Medical Simulation and Therapy Planning

The Reference Model Interface with ClinicalTrials.Gov

Improving Cortical Electrode Placement and Stimulation via Co-Simulation of Large-Scale Compartmental Neuronal and Multi-Resolution Admittance Method Models

Temporal Dynamics of Macrophage Plasticity in Bone Metastatic Prostate Cancer

Integrating Microscopic Variability in Systems Modeling

Design of Biomaterial Bioinorganic Interfaces Related to Mineralization

Thermal Response of Silk-Elastin-Like Protein Hydrogels: Integrating Experiments and Multiscale Computational Modeling

Prediction of EMG based on neural firing rates using stochastic dynamical operators

Multi-scale Modeling of Circadian Rhythms: From Metabolism to Regulation and Back in 24 hours

Comparison of Models of Hepatic Lobules at Varying Levels of Detail

Coupled multiscale modeling and pathway analysis for prediction of drug efficacy in cystic kidney diseases

arterioles 20-80 um, NO 0-100 nM, PO2 0-100 torr, time 0.1 s to minutes

Nitrite-mediated Vasodilation Quantified from In Vivo Studies in Rat Mesentery

A Mathematical Model for the Role of N₂O₃ in Enhancing Nitric Oxide Following Nitrite Infusion

IEEE Std 1906.1^TM-2015; and Reference Code NEMo, doi: 10.1109/TMBMC.2015.2465513

Applying Nanocommunication Modeling to Understand Calcium Ion Influx in Neurons and Impact on Kinesin Axonal Transport of BDNF Vesicles

Modelling the Airway Epithelium to Facilitate Cystic Fibrosis Drug Development

Sub-cellular to whole body lymphatic system, 10^-3 sec to hours

Mass Transport in the Lymphatic Vessels and Nodes

StochSS: An Integrated Development Environment for Simulation and Analysis of Discrete Stochastic Biochemical Models

A multiscale systems biology model to characterize antitumor immunity and evaluate biomarkers for immunotherapeutics

Systems Pharmacology Multiscale Model to Optimize Mono- and Combination-Therapy Regimens for Immune Checkpoint Inhibitors and Identify Potential Biomarkers

Multiscale modeling of vascularized bone regeneration in hybrid constructs of soft collagen gels and rigid scaffold

Development of a multiscale skin barrier model for de novo, in silico prediction

From the minute to the year, from the individual staff/patient scale to the OR suite and peripheral area scale.

hybrid ABM - stochastic ODE

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Multiscale Modeling of Surgical Flow in a Large Operating Room Suite: Understanding the Mechanism of Accumulation of Delays in Clinical Practice

Molecular Scale Prediction of Lidocaine Interaction with the Pore Domain of Human Na_V1.5

Multiscale Analysis of Trauma

Emulating Body Tissue Architectures for Computer-controlled Smart Material Design and Manufacture

Biophysically inspired model for functionalized nanocarrier adhesion to cell surface and the development of next-generation pharmacokinetic models

A multiscale model for predicting margination effects and transport of nanogels in blood vasculature: comparison of Dynamical Density Functional Theory and Monte Carlo based approaches

Cell Death as a Trigger for Morphogenesis of Bacterial Colonies

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sub-cellular, cellular, tissue

agent-based models, finite element models

celluar

DPD

subcelluar/celluar

CGMD/DPD

Patient-specific modeling of biomechanics and biorheology of red blood cells in sickle cell anemia

Biocellion: a large capacity modeling platform for multicellular biological systems

Effectiveness of UNAIDS targets and HIV vaccination across 127 countries

Hip Prostheses Lifetime Prediction via Simulation-based Engineering

Parallel Discrete Event Simulation of Neurons

Modeling Postsynaptic Current at the Glutamatergic Synapse of a CA1 Pyramidal Neuron: Development and Adaptation for Multi-Scale Simulations

Building Reproducible Dynamical Models with Tellurium 2.0: A Case Study using EGFR/Erk

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